Field experiment was carried out at the experimental research station of Nubaria, representing the sandy loam soil of Egypt. The study was done to evaluate the effect of nutrient ratios on growth and yield of Mediterranean barley varieties; Egyptian (Giza 126), Tunisian (Rihane), Algerian (Ras ElMouche) and Morocco (Adrar) grown under sufficient and deficit irrigation conditions. The foliar applied nutrient ratios were used in different proportions: (19N:19P:19K), (10N:55P:10K) and (6N:6P:43K). The higher values of chlorophyll content were obtained after application of (19N:19P:19K) in Adrar followed by Rihane barley variety whereas; the lowest ones were recorded at control treatments. The maximum values of the relative water content were observed after fertilizer ratios (10N:55P:10K) under water stress. Foliar application of fertilizer (6N:6P:43K) has a great impact on the K content especially at Ras El-Mouche and Ksar. Resulted data showed that the highest values of plant height, spike length and number of spike/m2 were attained at Adrar and Ras El Mouch under water stress condition. It's clear that the biological yield was highly at Rihane after application of (19N:19P:19K) and Ksar (6N:6P:43K) under deficit irrigation condition. Grain yield decreased with increasing drought stress and while, water use efficiency increased by increasing water stress. The foliar spraying of fertilizer ratio (19N:19P:19K) was better to improve the growth and yield parameters and nutrient contents under drought stress conditions of arid and semi-arid areas of North African countries. So, the balanced fertilization is important to maintain sustainable production of barley under water stress condition.