Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the novel coronavirus SARSCoV-2. The virus was discovered in Wuhan, Hubei Province, China. There are many vaccines for COVID19, including Russian Sputnik V (Gam-COVID-Vac). COVID-19 vaccination-induced hyperglycemia (ViHG) and sequelae have been documented in some cases. Objective: To determine that effect of Sputnik V vaccination on diabetic and non-diabetic patient. Methods: Blood samples were tested four times with the ACCU CHEK ACTIVE device, once before vaccination with the Sputnik V vaccine and three times after vaccination in diabetic and non-diabetic individuals. Results: all FBS were within the normal range for non-diabetic patient post vaccination (P value > 0.005) and for type-I diabetes mellitus there were fluctuation in blood glucose levels during three time intervals (P value <0.005) and it is significantly increased. Conclusion: Individual patient knowledge and engagement remains the cornerstone of diabetes management. Therefore, it is important to educate patients with diabetes about the phenomenon reported here, and future studies may shed more light on the underlying mechanisms.