Background: Prosthodontic rehabilitation involving teeth with periodontal disease is challenging. Restoration must be designed to withstand mastication with good esthetic and appropriate phonetic. Fixed bridge prosthesis are indicated to splint mobile teeth so that pressure on teeth will be stabilized. All-ceramic material often chose for their esthetics but clinical failures still occur, such as chipping and delamination. Ceramic material with high stiffness concentrates stress on the restoration, whereas materials with low stiffness transmit stress to cement layer and abutment teeth. Polyetheretherketone (PEEK) with its bio-inert properties and modulus elasticity 12 GPa similar to bone can be considered as an alternative to overcome this problem. Objectives: Rehabilitating missing teeth with PEEK anterior bridge prosthesis to restore teeth function with periodontal lesion and good esthetics. Case Report: A 45-year-old male patient came to Dental Hospital Universitas Sumatera Utara complaining lack of confidence due to missing front teeth and want to improve his appearance. The patient had a history of extracting his fractured front tooth due to motorcycle accident. Intraoral examination #11 #21 missing, #22 non-vital, mobility 1 with elongation. Radiographic examination revealed periodontal lesion in the apical 1/3 of the root. Treatment started with endodontic treatment #22 to avoid periodontic-endodontic infection. Fixed bridge 6-unit PEEK prosthesis were selected to splint lateral incisors along with other healthy abutments that complied with Ante's law. The shock absorber properties of PEEK provide an advantage for teeth with periodontal lesion because pressure will be distribute well thereby accelerate healing. Conclusion: Fixed bridge PEEK can be an alternative treatment especially in patients with periodontal lesion.