One of the most affected individuals during the pandemic is the nurses affecting their adversity quotient and job satisfaction. Research on adversity quotient and job satisfaction of nurses on duty is needed to improve their services in the hospitals. This study aimed to ascertain Adversity Quotients as a determinant of job satisfaction among staff nurses in Level III government hospitals during the COVID-19 pandemic in Central Luzon, Philippines. It utilized a quantitative approach to research, particularly descriptive-evaluative, descriptive-comparative, and descriptive-correlational designs, to ascertain adversity quotients as prognosticators of job satisfaction among staff nurses in the four levels III government hospitals in Central Luzon. Data were collected from 605 staff nurses employed in the four Level III Government Hospitals in Central Luzon using the adopted instruments from Stoltz's Adversity Quotient Profile® and Job Satisfaction Questionnaire of Spector. The results showed that the perceived level of adversity quotient of nurses was above average on endurance (WM=42.30) and reach (WM=38.53), average on control (WM=41.31), and below average on ownership (WM=38.46). Nurses agreed moderately on their job satisfaction towards supervision (4.56), and co-workers (WM=4.53). The nurse respondents agreed slightly on Promotion (WM=3.79), fringe benefits (3.73), nature of work (3.81) and operating conditions (4.08), and communication (WM=3.90). They disagreed slightly on contingent reward WM= (3.15) and pay (WM=2.53). The study reveals that there was a significant association between job satisfaction and the "reach" of the adversity quotient. The findings of this study may be used in clinical practice by nurses, and future research may be undertaken to validate the findings of this study.