Oxidative stress ensues when disturbance occurs between body’s antioxidants and reactive oxygen species ROS and this imbalance ushers in a series of ailments and other deleterious side effects. Antioxidants are cell’s defense against the ROS as they can either quench their thirst of electrons or can impede the whole chain reaction. Plants possess plethora of secondary metabolites and are a renowned source of antioxidants because of the aforementioned compounds. The point of present research was to investigate the in vivo and in vitroantioxidant effects of aqueous extracts of roots and leaves of psychrophytes (plants that grow below 0°C), Bergenia ciliata, Crassula pellucida, Ruta chalapensis, Rumex nepalensis, Palhinhaea cernua, Sedum forsterianum and Pinus roxburghii obtained from Minimerg, Pakistan on Dry Ice-Induced Paw inflammation in Albino Wistar Rats. DPPH radical scavenging activity was done along with antioxidant enzymes levels which include catalase, cyclooxygenase-2 (COX-2), superoxide dismutase (SOD), interleukin-6 (IL-6) and nitric oxide (NO2). Statistically, regarding DPPH radical scavenging activity % age inhibition was maximum of 91.88% for leaves of P.cernua and minimum 29.34 % for leaves of P.roxburghii at the same concentration (100µL). % age DPPH inhibition was also observed to increase with increasing concentration. Catalase activity was maximum for leaf extracts of S.forsterianum (16.26 U/ml) and minimum for leaf extract of B.ciliata (8.27 U/ml). SOD was maximum for roots of P.roxburghii(50.26 U/ml) and minimum for roots of C.pellucida (10.47U/ml). NO2 activity was maximally inhibited by roots of B.ciliata (0.546 µmol/L) while it was minimally inhibited by roots of P.cernua and R. chalepensis (1.788 µmol/L both). Maximum COX2 inhibition was seen in the in the leaf extracts of S. forsterianum (23.25 U/ml); while minimum COX-2 inhibition was observed in the leaf extract of C.pellucida (70.98 U/ml). As far as IL-6 is concerned, maximum inhibition of Interleukin-6 (IL-6) was demonstrated by root extracts of S.forsterianum(32.50 pg/L), while minimum inhibition of (IL-6) was demonstrated by root extracts of C.pellucida (180.00pg/L)These crude extracts could be purified and can be a beneficial source of antioxidants.