Helicobacter pylori are endemic, affect about half population of the world, and causes gastric ulcer, peptic ulcer, gastric cancer and classified as a class I carcinogen by the WHO. It is estimated 4.4 billion people were affected globally. This study was conducted to find out the prevalence of H. pylori
infection in different region of Mardan, KPK via questionnaire and personal interaction. For this purpose different hospitals were visited in order to collect the data of require patient after the consent approval from their parents and guardians. The detail information about, age, gender and area were collected from the subject of H. pylori infection. Total 260 patients were included in the study. The overall prevalence of H. pylori was found 46%. The gender wise analysis showed that the prevalence of H. pylori infection was dominant in male 55% as compared to female 45%. The age wise prevalence of infection in 10 to 25 years age group was found to be 58% and 26 to 40 years was found 34%. While the 40 and above years age group was 8%. According to the gender wise prevalence, male was more affected as compare to female. The age wise survey predicted that the lower age group (10 to 25 year) was more affected as compared to middle and higher age groups. The result also showed that urban areas were more affected by H. pylori as compare to rural areas.