1. Dr. TANYA NANDKEOLIAR - Assistant Professor, Department of Periodontology, Dental College, Regional Institute of Medical
Sciences, Imphal, Manipur, India.
2. Dr. CH. ANUPRIYA - Research Assistant, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India.
3. Dr. SUMITA BANERJEE - Assistant Professor, Department of Oral Pathology and Microbiology, Dental College, Regional
Institute of Medical Sciences, Imphal, Manipur, India.
4. Dr. SUSHMA KHURAIJAM - Professor and Head, Department of General Pathology, Regional Institute of Medical Sciences,
Imphal, Manipur, India.
5. Dr. D. B. NANDINI - Professor and Head, Department of Oral Pathology and Microbiology, Dental College, Regional
Institute of Medical Sciences, Imphal, Manipur, India.
6. Dr. KOIJAM SASHIKUMAR SINGH - Associate Professor, Department of Oral Medicine and Radiology. Dental College, Regional institute
of Medical Sciences, Imphal, Manipur, India.
7. Dr. PRAGYA PANDEY - Additional Professor, Department of Conservative Dentistry and Endodontics, Faculty of Dental
Sciences, King George’s Medical University, Lucknow.
Background: Oral cancer is one of the most common, life-threatening diseases all over the world. Several challenges are faced by developing countries in identifying and removing the potential risk factors associated with it. Early detection of oral premalignant lesions and conditions will help in the early treatment of the individuals and will downgrade their further progression into invasive oral cancer. Aims: To estimate the prevalence of oral premalignant lesions and conditions and to identify the associated risk factors in Manipur, North-East India. Methods: 1400 patients were recruited in this study and divided into two groups- With OPML and Without OPML groups. Individuals having signs and symptoms of oral precancerous lesions and conditions were included in the With OPML group while those without signs and symptoms of oral precancerous lesions/conditions were in the Without OPML group. Vital staining using toluidine blue dye was done in the With OPML group and a biopsy of these lesions and conditions was performed followed by histopathology to reach a confirmatory diagnosis. Statistical analysis: The chi-square test was applied to find significant differences among the two groups for tobacco habits, denture wear, and other risk factors. The significance level was set at P ≤ 0.05. Results: The study group consisted of 73.2% males and 26.8% females in the With OPML group, and 56.2% males and 43.8% females in the Without OPML group. The overall prevalence of OPML and conditions in our study was found to be 31% out of which 70% were associated with tobacco pouch keratosis followed by oral leukoplakia (17%), oral submucous fibrosis (6.8%) and oral lichen planus (5.8%). The risk factors associated with oral premalignant lesions and conditions were smoking and tobacco usage habits, alcohol consumption, stress, and diet. Conclusion: It is extremely crucial and the need of the hour to identify oral premalignant lesions and conditions as the early detection of these will reduce malignant transformation. This study helps us to find the prevalent Oral premalignant lesion or condition and additionally analyze the associated risk factors in the state of Manipur.
Oral Premalignant Conditions, Oral Premalignant Disorders, Oral Premalignant Lesions.