This study, based on data from 195 survey responses, using a Partial Least Square-Structural Equation Model (PLS-SEM) to examine the effect of digital transformation (i.e., cloud computing, websites, Internet of Things and digital leadership) on the supply chain pharmaceutical management in Jordanian context. Our findings reveal the significant and positive role of cloud computing, websites and digital leadership in enhancing supply chain Pharmaceutical Management in Jordan. This research provides valuable insights into exploring the role of digital transformation in enhancing the supply chain pharmaceutical management context. It addresses the gap in empirical literature regarding digital transformation research and enriches the field of the supply chain pharmaceutical management in Jordan.