1. NASEEM KHAN - PG Student, Department of Biochemistry, School of Medical Sciences and Research and Sharda
Hospital, Sharda University, Greater Noida, Uttar Pradesh, India.
2. MANOJ KUMAR NANDKEOLIAR - Professor, Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital,
Sharda University, Greater Noida, Uttar Pradesh, India.
3. SB SHARMA - Professor, Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital,
Sharda University, Greater Noida, Uttar Pradesh, India.
4. RAVIKANT SHARMA - Assistant Professor, Department of Biochemistry, School of Medical Sciences and Research and Sharda
Hospital, Sharda University, Greater Noida, Uttar Pradesh, India.
5. NIRUPMA GUPTA - Professor, Department of Anatomy, School of Medical Sciences and Research and Sharda Hospital,
Sharda University, Greater Noida, Uttar Pradesh, India.
6. THURAYA ABDULSALAM A.A. ALAZAZI - PhD Scholar, Department of Biochemistry, School of Medical Sciences and Research and Sharda
Hospital, Sharda University, Greater Noida, Uttar Pradesh, India.
Background: Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder often associated with insulin resistance (IR). Emerging research suggests vitamin D may influence insulin sensitivity and glucose metabolism. Objective: This study investigates the correlation between serum vitamin D levels and insulin resistance in patients with T2DM. Material & Method: A case-control study was conducted involving 90 Cases (45 T2DM patients) and 45 healthy controls aged 30 to 60 years. Fasting blood glucose, Serum insulin and vitamin D levels were estimated. HOMA-IR was calculated for insulin resistance. Results: T2DM were having higher mean fasting glucose levels (p < 0.001) as compared to controls. Although serum Insulin levels were within the normal range in cases and controls but significantly less in T2DM as compared to controls (p < 0.003). However, HOMA-IR was significantly elevated in T2DM as compared to controls (p < .001). Vitamin D levels were significantly decreased in T2DM as compared to controls (p = 0.003). Conclusion: The above findings suggest a significant inverse relationship between serum vitamin D levels and insulin resistance in T2DM patients. Vitamin D deficiency may contribute to insulin resistance, indicating the potential role of vitamin D supplementation in the management of T2DM.
Vitamin D, Insulin Resistance, Type 2 Diabetes Mellitus, HOMA-IR, Serum Insulin.