The present study investigated the relationship between information technologies, logistics agility and production collaboration with knowledge management as a mediator. A conceptual framework was developed to examine the direct links of information technologies with logistics agility, knowledge management and production collaboration, as well as the indirect links that run through knowledge management. The research method used in this study was quantitative research and the subjects were 542 managers of various industrial fields. Data analysis was done by using software of Structural Equation Modeling (SEM). The results showed that information technologies had a significant impact on improving communication efficiency, availability of information and coordination among the supply chain partners, thus positively affecting production collaboration. The findings also showed that logistics agility enhanced organizational responsiveness, operational flexibility and collaboration in decision making processes in dynamic market environments. In addition, a knowledge management acted as a significant mediator between the constructs of information technologies and logistics agility, as well as between logistics agility and production collaboration. This was reflected in the ability to share knowledge, learn from others, and integrate operational knowledge across supply chain networks. The study emphasized how transparent, trustful and strategically aligned production and logistics partners can be by using effective knowledge management practices, which promotes more efficient collaborative performance. The results pointed out that the prior investment of the information technology is necessary for the development of agile logistics capability and the establishment of a structured knowledge management system, in the interest of upgrading organization to sustainable production collaboration. The present study is a valuable contribution to the existing literature because of its empirical evidence on the interconnected role of technological capability, logistics agility and knowledge management in supporting production collaboration in current industrial contexts.