In a present situation of pandemic, the use of online mode of teaching and learning has grown as technology is used everywhere in education and training sectors. As per the scholar, “e-learning” is defined as the teaching method which is delivered via various multimedia platforms. Some investigators believed that curriculum of any course challenges or motivate the students. Their concern in their study was to identify the best tools for successful teaching and learning in online courses. Some scholars suggested that lack of experience regarding online course and technology among teaching faculty and students is a major drawback for the successful implementation of online programs. In spite of the volume of literature, a quick review revealed that there are variations in the attitude and perception of nursing students and teachers toward an online method of education. At present, only limited Indian studies are available related to the use of online classes, this review was done to synthesize the evidence. This systematic review is done to examine effect of online classes on knowledge and skill of the nursing fraternity.