Factors that affect ART adherence among people living with HIV (PLWH) based on Information, Motivation, and Behavioral Skill (IMB) model have not been systematically reviewed. The aim of this study was to review factors affecting ART adherence among PLWH based on IMB Model. This study used a systematic review design, using three electronic databases: PubMed, SCOPUS, and CINAHL to obtain articles from 2017 until 2022. The search strategy included the following terms based on MeSH (Medical Subject Headings) that were: information AND (behavior or behaviour or behavioral or behavioural) AND (motivation or motivate or motivating or engagement or participation) AND (adherence or compliance) AND (HIV or aids or acquired human immunodeficiency syndrome or human immunodeficiency virus). We searched the original, English version, also full paper articles. We used JBI critical checklist to criticize the articles. We got 276 studies identified through three electronic databases. In the end, we obtained 17 articles. IMB model predicted ART adherence among PLWH. The domain motivation was personal motivation, social motivation, risk and the pros and cons of methamphetamine use, support system and support deficit, conditional economic incentives, motivational interviewing. The domain behavioral were self-efficacy, skill, ART-taking skill, side effects management, staff behavior, respect patient autonomy, fairness, and apathy. This study is needed to develop determinant factors to promote ART adherence and intervention among PLWH.