A field experiment was conducted at the Division of Agriculture, Lovely Professional University, Jalandhar, and Punjab, India during spring and rabi 2021-22 in a randomized block design with eight weed treatments and three replications. The lowest weed density and biomass, highest weed control efficiency and maize growth parameters, yield characteristics, kernel and straw yields were recorded with post-emergence application of 2, 4-D Na combined with hand weeding at 60 DAS which was statistically at same level as hand weeding Twice (30 & 60 DAS) followed by (fb) pre-emergence application (PE) of Atrazine with Single hand weeding at 30 DAS. Pre-emergence application of pendimethalin combination with single hand weeding at 30 DAS, which was comparable to pendimethalin, showed higher cowpea seed yield, tiller yield and lower total weed density and biomass in subsequent pea tubs) PE closely followed by quizalofop-ethyl applied to cowpea. Based on this study, it was concluded that post-emergence application of 2, 4-D Na combined with one hand weeding at 60 DAS in spring maize and pre-emergence application of pendimethalin combination with single hand weeding at 30 DAS can be used for the most effective weed control to increase the productivity of spring maize followed by summer cowpea cropping system.