1,3,4-Thiadiazole and its derivatives continue to be of great interest to a large number of researchers.(1)1,3,4-thiadiazole is one of the most potent heterocyclic containing carbonic anhydrase and antibacterial inhibitor from the natural and synthetic origin. Till date many 1,3,4-thiadiazole nucleus containing drugs are available in the market such as acetazolamide, methazolamide, megazol.(2) 1,3,4 thiadiazoles exhibit divers biological activities possibly due to the presence of =N–C– S moiety. Moreover, some bi-heterocyclic compounds incorporating 1,3,4thiadiazole or 1,2,4triazole ring have been produced as antimicrobial agents.The cyclization of the compounds having thiosemicarbazide structure has shown to be an excellent strategy for the synthesis of 1,2,4 triazole, 1,3,4 thiadiazole, 1,3,4 oxadiazole and or 1,3,4 triazine derivatives.(3) Heterocycles bearing a symmetrical triazole or 1,3,4-thiadiazole moieties, represent an interesting class of compounds possessing a wide spectrum of biological activities such as anti-inflammatory, antiviral and antimicrobial properties. It has also been reported that derivatives of 1,2,4-triazole and 1,3,4- thiadiazole condensed nucleus systems exert diverse pharmacological activities such as anti-inflammatory, antitumor, antifungal and antibacterial.